Thomas Lincoln

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Name: Thomas L. Lincoln, MD

Elected ACMI Fellow: 1985

Birthdate: 1929

Degrees: MD Yale, 1960

Current Position: Professor Emeritus at the University of Southern California (ret). Senior Scientist at Rand Corporation (ret)

Current email:

Professional Affiliations:

Professional Activities:

Honors and Awards:

Other Works:

Other Information:

Curriculum Vitae:

Selected Publications:

The Electronic Medical Record: A Challenge for Computer Science to Develop Clinically
and Socially Relevant Computer Systems to Coordinate Information for patient Care and Analysis. 
Inf. Soc. 9(2): (1993)

The Computer-Based Patient Record: Issues of Organization, Security and Confidentiality. DBSec 1991: 1-19

Codifying Medical Records in XML: Philosophy and Engineering. World Wide Web Journal 2(4): 149-152 (1997)

Dependability of Medical Computing. FTCS 1995: 541

The Electronic Medical Record: A Challenge for Computer Science to Develop Clinically and
Socially Relevant Computer Systems to Coordinate Information for patient Care and Analysis. Inf. Soc. 9(2): (1993)

The Computer-Based Patient Record: Issues of Organization, Security and Confidentiality. DBSec 1991: 1-19

An historical perspective on clinical laboratory information systems. History of Medical Informatics 1987: 117-121

Adherence to HIV Treatment and Care Among Previously Homeless Jail Detainees.
Chen NE, Meyer JP, Avery AK, Draine J, Flanigan TP, Lincoln T, Spaulding AC, Sp\
ringer SA, Altice FL.
AIDS Behav. 2011 Nov 8. [Epub ahead of print]
PMID: 22065234

Mechanism of glucose-6-phosphate dehydrogenase-mediated regulation of coronary \
artery contractility.
Ata H, Rawat DK, Lincoln T, Gupte SA.
Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2054-63. Epub 2011 Mar 11.
PMID: 21398595

Strategies to enhance linkages between care for HIV/AIDS in jail and community \
Draine J, Ahuja D, Altice FL, Arriola KJ, Avery AK, Beckwith CG, Booker CA, Fer\
guson A, Figueroa H, Lincoln T, Ouellet LJ, Porterfield J, Spaulding AC, Tinsle\
y MJ.
AIDS Care. 2011 Mar;23(3):366-77.
PMID: 21347900

Stabilization of cGMP-dependent protein kinase G (PKG) expression in vascular s\
mooth muscle cells: contribution of 3'UTR of its mRNA.
Sellak H, Lincoln TM, Choi CS.
J Biochem. 2011 Apr;149(4):433-41. Epub 2011 Feb 3.
PMID: 21292805

cGMP-dependent protein kinase and the regulation of vascular smooth muscle cell\
 gene expression: possible involvement of Elk-1 sumoylation.
Choi C, Sellak H, Brown FM, Lincoln TM.
Am J Physiol Heart Circ Physiol. 2010 Nov;299(5):H1660-70. Epub 2010 Aug 27.
PMID: 20802137

Glucose downregulation of PKG-I protein mediates increased thrombospondin1-depe\
ndent TGF-{beta} activity in vascular smooth muscle cells.
Wang S, Lincoln TM, Murphy-Ullrich JE.
Am J Physiol Cell Physiol. 2010 May;298(5):C1188-97. Epub 2010 Feb 17.
PMID: 20164378

Resumption of smoking after release from a tobacco-free correctional facility.
Lincoln T, Tuthill RW, Roberts CA, Kennedy S, Hammett TM, Langmore-Avila E, Con\
klin TJ.
J Correct Health Care. 2009 Jul;15(3):190-6. Epub 2009 Apr 29.
PMID: 19477804

Effects of chronic hypoxia on soluble guanylate cyclase activity in fetal and a\
dult ovine cerebral arteries.
Pearce WJ, Williams JM, White CR, Lincoln TM.
J Appl Physiol. 2009 Jul;107(1):192-9. Epub 2009 Apr 30.
PMID: 19407253

Cyclic GMP specifically suppresses Type-Ialpha cGMP-dependent protein kinase ex\
pression by ubiquitination.
Dey NB, Busch JL, Francis SH, Corbin JD, Lincoln TM.
Cell Signal. 2009 Jun;21(6):859-66. Epub 2009 Jan 8.
PMID: 19168131

Sex and age correlates of Chlamydia prevalence in adolescents and adults enteri\
ng correctional facilities, 2005: implications for screening policy.
Joesoef MR, Weinstock HS, Kent CK, Chow JM, Boudov MR, Parvez FM, Cox T, Lincol\
n T, Miller JL, Sternberg M; Corrections STD Prevalence Monitoring Group.
Sex Transm Dis. 2009 Feb;36(2 Suppl):S67-71.
PMID: 19125147

Glucose down-regulation of cGMP-dependent protein kinase I expression in vascul\
ar smooth muscle cells involves NAD(P)H oxidase-derived reactive oxygen species\
Liu S, Ma X, Gong M, Shi L, Lincoln T, Wang S.
Free Radic Biol Med. 2007 Mar 15;42(6):852-63. Epub 2007 Jan 3.
PMID: 17320767

Myosin phosphatase regulatory pathways: different functions or redundant functi\
Lincoln TM.
Circ Res. 2007 Jan 5;100(1):10-2. Review. No abstract available.
PMID: 17204659

A cost-effectiveness evaluation of a jail-based chlamydia screening program for\
 men and its impact on their partners in the community.
Gift TL, Lincoln T, Tuthill R, Whelan M, Briggs LP, Conklin T, Irwin KL.
Sex Transm Dis. 2006 Oct;33(10 Suppl):S103-10.
PMID: 17003677

US experience of smoke-free prisons.
Lincoln T, Chavez RS, Langmore-Avila E.
BMJ. 2005 Dec 17;331(7530):1473. No abstract available.
PMID: 16356992

Facilitators and barriers to continuing healthcare after jail: a community-inte\
grated program.
Lincoln T, Kennedy S, Tuthill R, Roberts C, Conklin TJ, Hammett TM.
J Ambul Care Manage. 2006 Jan-Mar;29(1):2-16.
PMID: 16340615

Regulation of vascular smooth muscle cell phenotype by cyclic GMP and cyclic GM\
P-dependent protein kinase.

Lincoln TM, Wu X, Sellak H, Dey N, Choi CS.
Front Biosci. 2006 Jan 1;11:356-67. Review.
PMID: 16146737

Protein kinase G transmits the cardioprotective signal from cytosol to mitochon\
Costa AD, Garlid KD, West IC, Lincoln TM, Downey JM, Cohen MV, Critz SD.
Circ Res. 2005 Aug 19;97(4):329-36. Epub 2005 Jul 21.
PMID: 16037573

Inhibition of cGMP-dependent protein kinase reverses phenotypic modulation of v\
ascular smooth muscle cells.
Dey NB, Foley KF, Lincoln TM, Dostmann WR.
J Cardiovasc Pharmacol. 2005 May;45(5):404-13.
PMID: 15821435

Upstream stimulatory factors (USF-1/USF-2) regulate human cGMP-dependent protei\
n kinase I gene expression in vascular smooth muscle cells.
Sellak H, Choi C, Browner N, Lincoln TM.
J Biol Chem. 2005 May 6;280(18):18425-33. Epub 2005 Feb 28.
PMID: 1574Warner HR, Olmsted CM, Rutherford BD. HELP--a program for -->
--medical decision-making. Comput Biomed Res. 1972 Feb;5(1):65b1164

Regulation of cGMP-dependent protein kinase expression by soluble guanylyl cycl\
ase in vascular smooth muscle cells.
Browner NC, Dey NB, Bloch KD, Lincoln TM.
J Biol Chem. 2004 Nov 5;279(45):46631-6. Epub 2004 Aug 26.
PMID: 15337747

Cyclic GMP and phosphodiesterase 5 inhibitor therapies: what's on the horizon?
Lincoln TM.
Mol Pharmacol. 2004 Jul;66(1):11-3. No abstract available.
PMID: 15213291

Exogenous NO triggers preconditioning via a cGMP- and mitoKATP-dependent mechan\
Qin Q, Yang XM, Cui L, Critz SD, Cohen MV, Browner NC, Lincoln TM, Downey JM.
Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H712-8. Epub 2004 Mar 25.
PMID: 15044194

Genetic modification of smooth muscle cells to control phenotype and function i\
n vascular tissue engineering.
Stegemann JP, Dey NB, Lincoln TM, Nerem RM.
Tissue Eng. 2004 Jan-Feb;10(1-2):189-99.
PMID: 15009945

Downregulation of cGMP-dependent protein kinase expression by inflammatory cyto\
kines in vascular smooth muscle cells.

Browner NC, Sellak H, Lincoln TM.
Am J Physiol Cell Physiol. 2004 Jul;287(1):C88-96. Epub 2004 Feb 25.
PMID: 14985234

Expression of constitutively active cGMP-dependent protein kinase prevents gluc\
ose stimulation of thrombospondin 1 expression and TGF-beta activity.
Wang S, Wu X, Lincoln TM, Murphy-Ullrich JE.
Diabetes. 2003 Aug;52(8):2144-50.
PMID: 12882934

cGMP-dependent protein kinase expression restores contractile function in cultu\
red vascular smooth muscle cells.
Brophy CM, Woodrum DA, Pollock J, Dickinson M, Komalavilas P, Cornwell TL, Linc\
oln TM.
J Vasc Res. 2002 Mar-Apr;39(2):95-103.
PMID: 12011581

Sp1 transcription factor as a molecular target for nitric oxide-- and cyclic nucleotide--mediated
suppression of cGMP-dependent protein kinase-Ialpha expression in vascular smooth muscle cells.
Sellak H, Yang X, Cao X, Cornwell T, Soff GA, Lincoln T.
Circ Res. 2002 Mar 8;90(4):405-12.
PMID: 11884369


Biomod Simulation of Pharmacokinetics for Leukemia Chemotherapy,1973

Clinical Significance of Simulation and Modeling in Leukemia Chemotherapy, 1972

Medical Computing - Cons and Pros, 1973

Predicting Progress, Recognizing Breakthroughs,and Evaluating Performance in the
Treatement of Leukemia, 1972

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