Daniel Masys

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Name: Daniel R. Masys, MD

Elected ACMI Fellow: 1987


Degrees: MD, Ohio State

Current Position: Affiliate Professor Biomedical and Health Informatics University of Washington School of Medicine

Current email: dmasys@uw.edu

Professional Affiliations:

Professional Activities: Chairman, Biomedical Informatics, VICC, Presents the Informatics Year in Review at the annual American Medical Informatics Association Symposium. Chair, NIH Biomedical Computing and Health Informatics study section Chair, caBIG oversight subcommittee of the NCI Board of Scientific Advisors.

Honors and Awards: Institute of Medicine of the National Academy of Sciences, Diplomate of the American Board of Internal Medicine in Medicine, Hematology, and Medical Oncology

Other Works:

Other Information: Dr. Daniel R. Masys retired from Vanderbilt in May of 2011.

Curriculum Vitae:

Selected Publications:

Presentation of the Morris F. Collen Award to Donald A. B. Lindberg, MD, J Am
Med Inform Assoc. 1998 Mar-Apr; 5(2): 214–216.

Ramirez AH, Shi Y, Schildcrout JS, Delaney JT, Xu H, Oetjens MT,
Zuvich RL, Basford MA, Bowton E, Jiang M, Speltz P, Zink R, Cowan J,
Pulley JM, Ritchie MD, Masys DR, Roden DM, Crawford DC, Denny
JC. Predicting warfarin dosage in European-Americans and
African-Americans using DNA samples linked to an electronic health
record. Pharmacogenomics. 2012 Mar;13(4):407-18. Epub 2012 Feb 13.              

Masys DR, Jarvik GP, Abernethy NF, Anderson NR, Papanicolaou GJ,
Paltoo DN, Hoffman MA, Kohane IS, Levy HP. Technical desiderata for
the integration of genomic data into Electronic Health Records. J
Biomed Inform. 2011 Dec 27. [Epub ahead of print]

Pathak J, Pan H, Wang J, Kashyap S, Schad PA, Hamilton CM, Masys DR,
Chute CG.  Evaluating Phenotypic Data Elements for Genetics and
Epidemiological Research: Experiences from the eMERGE and PhenX
Network Projects. AMIA Summits Transl Sci Proc. 2011;2011:41-5. Epub            
2011 Mar 7.

Denny JC, Crawford DC, Ritchie MD, Bielinski SJ, Basford MA, Bradford
Y, Chai HS, Bastarache L, Zuvich R, Peissig P, Carrell D, Ramirez AH,
Pathak J, Wilke RA, Rasmussen L, Wang X, Pacheco JA, Kho AN, Hayes MG,
Weston N, Matsumoto M, Kopp PA, Newton KM, Jarvik GP, Li R, Manolio
TA, Kullo IJ, Chute CG, Chisholm RL, Larson EB, McCarty CA, Masys DR,
Roden DM, de Andrade M. Variants near FOXE1 are associated with
hypothyroidism and other thyroid conditions: using electronic medical
records for genome- and phenome-wide studies. Am J Hum Genet. 2011 Oct
7;89(4):529-42. doi: 10.1016/j.ajhg.2011.09.008.                                

Poulose BK, Kummerow KL, Nealon WH, Shelton JS, Masys DR, Holzman
MD. Biliary obstruction during cholecystectomy: endoscopic retrograde
cholangiopancreatography, evade, or explore? Am Surg. 2011

Xu H, Jiang M, Oetjens M, Bowton EA, Ramirez AH, Jeff JM, Basford MA,
Pulley JM, Cowan JD, Wang X, Ritchie MD, Masys DR, Roden DM, Crawford
DC, Denny JC.  Facilitating pharmacogenetic studies using electronic
health records and natural-language processing: a case study of
warfarin. J Am Med Inform Assoc.  2011 Jul-Aug;18(4):387-91.                    

Pathak J, Wang J, Kashyap S, Basford M, Li R, Masys DR, Chute
CG. Mapping clinical phenotype data elements to standardized metadata
repositories and controlled terminologies: the eMERGE Network
experience. J Am Med Inform Assoc.  2011 Jul-Aug;18(4):376-86. Epub             
2011 May 19.

Morgan EE, Woods SP, Delano-Wood L, Bondi MW, Grant I; HIV                      
Neurobehavioral Research Program (HNRP) Group. Intraindividual
variability in HIV infection: Evidence for greater neurocognitive
dispersion in older HIV seropositive adults.  Neuropsychology. 2011
Sep;25(5):645-54. doi: 10.1037/a0023792.  21574712;                             

Zogg JB, Woods SP, Weber E, Doyle K, Grant I; HIV Neurobehavioral               
Research Programs (HNRP) Group. Are time- and event-based prospective
memory comparably affected in HIV infection? Arch Clin
Neuropsychol. 2011 Apr;26(3):250-9. Epub 2011 Apr 1.                            

Woods SP, Weber E, Weisz BM, Twamley EW, Grant I; HIV Neurobehavioral           
Research Programs Group. Prospective memory deficits are associated
with unemployment in persons living with HIV infection. Rehabil
Psychol. 2011 Feb;56(1):77-84.                                                  

Scott JC, Woods SP, Vigil O, Heaton RK, Schweinsburg BC, Ellis RJ,
Grant I, Marcotte TD; San Diego HIV Neurobehavioral Research Center             
(HNRC) Group. A neuropsychological investigation of multitasking in
HIV infection: implications for everyday
functioning. Neuropsychology. 2011 Jul;25(4):511-9.                             

Cysique LA, Franklin D Jr, Abramson I, Ellis RJ, Letendre S, Collier
A, Clifford D, Gelman B, McArthur J, Morgello S, Simpson D, McCutchan
JA, Grant I, Heaton RK; CHARTER Group; HNRC Group. Normative data and           
validation of a regression based summary score for assessing
meaningful neuropsychological change. J Clin Exp Neuropsychol. 2011
Jun;33(5):505-22. Epub 2011 Mar 7.  PMID: 21391011; PubMed Central              

Iudicello JE, Weber E, Grant I, Weinborn M, Woods SP; HIV                       
Neurobehavioral Research Center (HNRC) Group. Misremembering future
intentions in methamphetamine-dependent individuals. Clin
Neuropsychol. 2011 Feb;25(2):269-86.                                            

Harris PA, Swafford JA, Edwards TL, Zhang M, Nigavekar SS, Yarbrough
TR, Lane LD, Helmer T, Lebo LA, Mayo G, Masys DR, Bernard GR, Pulley
JM. StarBRITE: the Vanderbilt University Biomedical Research
Integration, Translation and Education portal. J Biomed Inform. 2011
Aug;44(4):655-62. Epub 2011 Feb 15.                                             

McCarty CA, Chisholm RL, Chute CG, Kullo IJ, Jarvik GP, Larson EB, Li
R, Masys DR, Ritchie MD, Roden DM, Struewing JP, Wolf WA; eMERGE                
Team. The eMERGE Network: a consortium of biorepositories linked to
electronic medical records data for conducting genomic studies. BMC
Med Genomics. 2011 Jan 26;4:13.                                                 

Malaspina L, Woods SP, Moore DJ, Depp C, Letendre SL, Jeste D, Grant
I; HIV Neurobehavioral Research Programs (HNRP) Group. Successful               
cognitive aging in persons living with HIV infection. J
Neurovirol. 2011 Feb;17(1):110-9. Epub 2010 Nov 30.                             

Denny JC, Ritchie MD, Crawford DC, Schildcrout JS, Ramirez AH, Pulley
JM, Basford MA, Masys DR, Haines JL, Roden DM. Identification of
genomic predictors of atrioventricular conduction: using electronic
medical records as a tool for genome science. Circulation. 2010 Nov
16;122(20):2016-21. Epub 2010 Nov 1.

Woods SP, Weber E, Cameron MV, Dawson MS, Delano-Wood L, Bondi MW,
Grant I; HIV Neurobehavioral Research Center (HNRC) Group. Spontaneous          
strategy use protects against visual working memory deficits in older
adults infected with HIV. Arch Clin Neuropsychol. 2010
Dec;25(8):724-33. Epub 2010 Sep 27.                                             

Scott JC, Woods SP, Carey CL, Weber E, Bondi MW, Grant I; HIV                   
Neurobehavioral Research Center (HNRC) Group. Neurocognitive
consequences of HIV infection in older adults: an evaluation of the
"cortical" hypothesis. AIDS Behav. 2011 Aug;15(6):1187-96.                      

Bousman CA, Cherner M, Emory KT, Barron D, Grebenstein P, Atkinson JH,
Heaton RK, Grant I; HNRC Group. Preliminary evidence of motor                   
impairment among polysubstance 3,4-methylenedioxymethamphetamine users
with intact neuropsychological functioning. J Int Neuropsychol
Soc. 2010 Nov;16(6):1047-55.  Epub 2010 Aug 25.                                 

Schildcrout JS, Basford MA, Pulley JM, Masys DR, Roden DM, Wang D,
Chute CG, Kullo IJ, Carrell D, Peissig P, Kho A, Denny JC. An
analytical approach to characterize morbidity profile dissimilarity
between distinct cohorts using electronic medical records. J Biomed
Inform. 2010 Dec;43(6):914-23. Epub 2010 Aug 3.                                 

Spragg RG, Masys DR, Sergeant D, Lawrie T, Taut FJ. An informatics
strategy to assure enrollment criteria compliance in studies of the
critically ill.  Contemp Clin Trials. 2010 Nov;31(6):530-5. Epub 2010           
Aug 4.

Zogg JB, Woods SP, Weber E, Iudicello JE, Dawson MS, Grant I; HIV               
Neurobehavioral Research Center Group. HIV-associated prospective
memory impairment in the laboratory predicts failures on a
semi-naturalistic measure of health care compliance. Clin
Neuropsychol. 2010 Aug;24(6):945-62. Epub 2010 Jul 20.                          

Posada C, Moore DJ, Woods SP, Vigil O, Ake C, Perry W, Hassanein TI,
Letendre SL, Grant I; HIV Neurobehavioral Research Center                       
Group. Implications of hepatitis C virus infection for behavioral
symptoms and activities of daily living. J Clin Exp Neuropsychol. 2010

Pulley J, Hassan NN, Bernard GR, Jirjis JN, Schildcrout J, Robertson
D, Masys DR, Harris P. Identifying unpredicted drug benefit through
query of patient experiential knowledge: a proof of concept web-based
system. Clin Transl Sci.  2010 Jun;3(3):98-103.                                 

Cesar C, Shepherd BE, Krolewiecki AJ, Fink VI, Schechter M, Tuboi SH,
Wolff M, Pape JW, Leger P, Padgett D, Madero JS, Gotuzzo E, Sued O,
McGowan CC, Masys DR, Cahn PE; Caribbean, Central and South America             
Network for HIV Research (CCASAnet) Collaboration of the International
Epidemiologic Databases to Evaluate AIDS (IeDEA) Program. Rates and
reasons for early change of first HAART in HIV-1-infected patients in
7 sites throughout the Caribbean and Latin America.  PLoS One. 2010
Jun 1;5(6):e10490.                                                              

Pulley J, Clayton E, Bernard GR, Roden DM, Masys DR. Principles of
human subjects protections applied in an opt-out, de-identified
biobank. Clin Transl Sci. 2010 Feb;3(1):42-8.                                   

Gupta S, Woods SP, Weber E, Dawson MS, Grant I; HIV Neurobehavioral             
Research Center (HNRC) Group. Is prospective memory a dissociable
cognitive function in HIV infection? J Clin Exp Neuropsychol. 2010
Oct;32(8):898-908. Epub 2010 Apr 27.                                            

Ritchie MD, Denny JC, Crawford DC, Ramirez AH, Weiner JB, Pulley JM,
Basford MA, Brown-Gentry K, Balser JR, Masys DR, Haines JL, Roden
DM. Robust replication of genotype-phenotype associations across
multiple diseases in an electronic medical record. Am J Hum
Genet. 2010 Apr 9;86(4):560-72. Epub 2010 Apr 1. Erratum in: Am J Hum           
Genet. 2010 Aug 13;87(2):310.                                                   

Cysique LA, Letendre SL, Ake C, Jin H, Franklin DR, Gupta S, Shi C, Yu
X, Wu Z, Abramson IS, Grant I, Heaton RK; HIV Neurobehavioral Research          
Center group.  Incidence and nature of cognitive decline over 1 year
among HIV-infected former plasma donors in China. AIDS. 2010 Apr

Iudicello JE, Woods SP, Vigil O, Scott JC, Cherner M, Heaton RK,
Atkinson JH, Grant I; HIV Neurobehavioral Research Center (HNRC)                
Group. Longer term improvement in neurocognitive functioning and
affective distress among methamphetamine users who achieve stable
abstinence. J Clin Exp Neuropsychol.  2010 Aug;32(7):704-18. Epub 2010          
Mar 2.

Woods SP, Dawson MS, Weber E, Grant I; HIV Neurobehavioral Research             
Center (HNRC) Group. The semantic relatedness of cue-intention
pairings influences event-based prospective memory failures in older
adults with HIV infection. J Clin Exp Neuropsychol. 2010
Apr;32(4):398-407. Epub 2009 Sep 17.                                            

Ances BM, Sisti D, Vaida F, Liang CL, Leontiev O, Perthen JE, Buxton
RB, Benson D, Smith DM, Little SJ, Richman DD, Moore DJ, Ellis RJ;              
HNRC group.  Resting cerebral blood flow: a potential biomarker of the
effects of HIV in the brain. Neurology. 2009 Sep 1;73(9):702-8.                 

Ances BM, Bhatt A, Vaida F, Rosario D, Alexander T, Marquie-Beck J,
Ellis RJ, Letendre S, Grant I, McCutchan JA; HIV Neurobehavioral                
Research Center (HNRC) Group. Role of metabolic syndrome components in
human immunodeficiency virus-associated stroke. J Neurovirol. 2009

Wehbe FH, Brown SH, Massion PP, Gadd CS, Masys DR, Aliferis CF. A
novel information retrieval model for high-throughput molecular
medicine modalities.  Cancer Inform. 2009 Feb 9;8:1-17.                         

Tuboi SH, Schechter M, McGowan CC, Cesar C, Krolewiecki A, Cahn P,
Wolff M, Pape JW, Padgett D, Madero JS, Gotuzzo E, Masys DR, Shepherd
BE. Mortality during the first year of potent antiretroviral therapy
in HIV-1-infected patients in 7 sites throughout Latin America and the
Caribbean. J Acquir Immune Defic Syndr.  2009 Aug 15;51(5):615-23.              

Bousman CA, Cherner M, Ake C, Letendre S, Atkinson JH, Patterson TL,
Grant I, Everall IP; HNRC Group. Negative mood and sexual behavior              
among non-monogamous men who have sex with men in the context of
methamphetamine and HIV. J Affect Disord. 2009
Dec;119(1-3):84-91. Epub 2009 May 5.                                            

Achim CL, Adame A, Dumaop W, Everall IP, Masliah E; Neurobehavioral             
Research Center. Increased accumulation of intraneuronal amyloid beta
in HIV-infected patients. J Neuroimmune Pharmacol. 2009
Jun;4(2):190-9. Epub 2009 Mar 17.

Tatro ET, Everall IP, Masliah E, Hult BJ, Lucero G, Chana G,
Soontornniyomkij V, Achim CL; HIV Neurobehavioral Research                      
Center. Differential expression of immunophilins FKBP51 and FKBP52 in
the frontal cortex of HIV-infected patients with major depressive
disorder. J Neuroimmune Pharmacol. 2009 Jun;4(2):218-26.  Epub 2009             
Feb 6.

Khanlou N, Moore DJ, Chana G, Cherner M, Lazzaretto D, Dawes S, Grant
I, Masliah E, Everall IP; HNRC Group. Increased frequency of                    
alpha-synuclein in the substantia nigra in human immunodeficiency
virus infection. J Neurovirol. 2009 Apr;15(2):131-8.                            

Smith DM, Zárate S, Shao H, Pillai SK, Letendre SL, Wong JK, Richman
DD, Frost SD, Ellis RJ; HNRC Group. Pleocytosis is associated with              
disruption of HIV compartmentalization between blood and cerebral
spinal fluid viral populations.  Virology. 2009 Mar
1;385(1):204-8. Epub 2008 Dec 18.                                               

Childers ME, Woods SP, Letendre S, McCutchan JA, Rosario D, Grant I,
Mindt MR, Ellis RJ; San Diego HIV Neurobehavioral Research Center               
Group. Cognitive functioning during highly active antiretroviral
therapy interruption in human immunodeficiency virus type 1
infection. J Neurovirol. 2008 Nov;14(6):550-7.                                  

Heaton RK, Cysique LA, Jin H, Shi C, Yu X, Letendre S, Franklin DR,
Ake C, Vigil O, Atkinson JH, Marcotte TD, Grant I, Wu Z; San Diego HIV          
Neurobehavioral Research Center Group. Neurobehavioral effects of
human immunodeficiency virus infection among former plasma donors in
rural China. J Neurovirol. 2008 Nov;14(6):536-49. Erratum in: J                 
Neurovirol. 2010 Mar;16(2):185-8.                                               

Woods SP, Moran LM, Dawson MS, Carey CL, Grant I; HIV Neurobehavioral           
Research Center (HNRC) Group. Psychometric characteristics of the
memory for intentions screening test. Clin Neuropsychol. 2008

Iudicello JE, Woods SP, Weber E, Dawson MS, Scott JC, Carey CL, Grant
I; HIV Neurobehavioral Research Center (HNRC) Group. Cognitive                  
mechanisms of switching in HIV-associated category fluency deficits. J
Clin Exp Neuropsychol. 2008 Oct;30(7):797-804. Epub 2008 Mar 4.                 

Dawes S, Suarez P, Casey CY, Cherner M, Marcotte TD, Letendre S, Grant
I, Heaton RK; HNRC Group. Variable patterns of neuropsychological               
performance in HIV-1 infection. J Clin Exp Neuropsychol. 2008
Aug;30(6):613-26. Epub 2008 Mar 4.                                              

Vigil O, Posada C, Woods SP, Atkinson JH, Heaton RK, Perry W,
Hassanein TI, Grant I, Letendre SL; HIV Neurobehavioral Research                
Center (HNRC) Group.  Impairments in fine-motor coordination and speed
of information processing predict declines in everyday functioning in
hepatitis C infection. J Clin Exp Neuropsychol. 2008
Oct;30(7):805-15. Epub 2008 Mar 4.                                              

Masys DR, Ellison D, Stead WW. Presentation of the 2007 Morris
F. Collen award to William W. Stead, MD, including comments from
recipient. J Am Med Inform Assoc. 2008 May-Jun;15(3):302-6. Epub 2008           
Feb 28.

Woods SP, Moran LM, Carey CL, Dawson MS, Iudicello JE, Gibson S, Grant
I, Atkinson JH; HIV Neurobehavioral Research Center Group. Prospective          
memory in HIV infection: is "remembering to remember" a unique
predictor of self-reported medication management? Arch Clin
Neuropsychol. 2008 May;23(3):257-70. Epub 2008 Feb 19.                          

Duda SN, Cushman C, Masys DR. An XML model of an enhanced data
dictionary to facilitate the exchange of pre-existing clinical
research data in international studies. Stud Health Technol
Inform. 2007;129(Pt 1):449-53.                                                  

McGowan CC, Cahn P, Gotuzzo E, Padgett D, Pape JW, Wolff M, Schechter
M, Masys DR. Cohort Profile: Caribbean, Central and South America
Network for HIV research (CCASAnet) collaboration within the
International Epidemiologic Databases to Evaluate AIDS (IeDEA)
programme. Int J Epidemiol. 2007 Oct;36(5):969-76. Epub 2007 Sep                
10. Review.

Kohane IS, Masys DR, Altman RB. The incidentalome: a threat to genomic
medicine. JAMA. 2006 Jul 12;296(2):212-5. Erratum in: JAMA. 2006 Sep            

Fink JL, Drewes S, Patel H, Welsh JB, Masys DR, Corbeil J, Gribskov
M. 2HAPI: a microarray data analysis system. Bioinformatics. 2003 Jul

Madsen E, Masys DR, Miller RA. HIPAA Possumus. J Am Med Inform
Assoc. 2003 May-Jun;10(3):294.                                                  

Masys DR. Effects of current and future information technologies on
the health care workforce. Health Aff (Millwood). 2002


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